Spinal Tuberculosis: Rethinking an Old Disease

Spinal Tuberculosis: Rethinking an Old Disease

Despite of the fact that the earliest cases of Spinal Tuberculosis date from 2400 BC, the first modern description was made in 1779 by Sir Percival Pott in the European population. The improvement of public health measures and the introduction of effective anti-tuberculosis drugs have made the infection virtually eradicated in developed countries. However, migration phenomena, the infection by ...

Tuberculosis: new facets of an old disease.

Tuberculosis: novel approaches to an old disease.

Tuberculosis (TB), one of the most ancient and deadly diseases of mankind, has ravaged human communities since the beginning of civilization, and still remains one of the most devastating infectious diseases in the 21 st century. The latest report released by the World Health Organization estimates that 1.45 million deaths each year are due to TB, with 9 million incident cases and 14 million pr...

Tuberculosis: New Aspects of an Old Disease

Tuberculosis is an ancient infectious disease that remains a threat for public health around the world. Although the etiological agent as well as tuberculosis pathogenesis is well known, the molecular mechanisms underlying the host defense to the bacilli remain elusive. In this paper we focus on the innate immunity of this disease reviewing well-established and consensual mechanisms like Mycoba...

Miliary tuberculosis: new insights into an old disease.

Miliary tuberculosis is a potentially lethal form of tuberculosis resulting from massive lymphohaematogeneous dissemination of Mycobacterium tuberculosis bacilli. The emergence of the HIV/AIDS pandemic and widespread use of immunosuppressive drugs has changed the epidemiology of miliary tuberculosis. Impaired cell-mediated immunity underlies the disease's development. Clinical manifestations ar...